Daniel Stone, PhD
Principal Staff Scientist, Jerome Lab
Infectious Disease Sciences, Vaccine and Infectious Disease Division, Fred Hutch
Research interests involve study of the interplay between viruses and their hosts to develop virus-based gene therapies. Mainly focused on the development and preclinical evaluation of viral therapeutics targeting cancer and other endocrine, musculoskeletal, neurological, or hematological diseases. Research at Fred Hutch primarily centers on the development of novel curative treatments for persistent viral infections that are currently incurable, impact millions globally, and may cause cancer.
Education
University of Manchester, UK, 2001, PhD (Gene Therapy)
University of Manchester, UK, 1997, BSc (Biochemistry)
Research Expertise
Study of virus biology in vitro and in vivo (infection/replication/pathogenesis) using molecular virology, cell culture, and animal models of disease
Investigation of the interplay between viruses and host immune responses during viral infection
Development of novel viral vector systems (AAV/adenovirus) for therapeutic gene delivery
Evaluation of viral vector biodistribution, efficacy and safety in small and large animal models of disease
Development of animal models for the preclinical assessment of novel gene therapies
Development and assessment of gene editing therapeutics targeting infectious diseases
Current Projects
Development of antiviral gene editing therapeutics that target HBV
Development of liver-humanized mouse models to study HBV
Assessment of lipid nanoparticles for gene delivery to HBV-infected liver-humanized mice
Development of novel viral vectors that target sites of persistent viral infection (HBV, HIV or HSV) including liver, sensory ganglia and CD4+ T cells
Dr. Stone is a member of the Jerome Lab.