Kaposi sarcoma is the second most common cancer in adult men, after prostate cancer, in Uganda, said Dr. Solomon Kibudde, a Ugandan physician in his sixth year at the UCI. It is also a common cancer among women, after cervical cancer (another infection-related cancer caused by certain strains of the human papillomavirus) and breast cancer.
Driving the high numbers is the HIV/AIDS epidemic. People with AIDS are vulnerable to infection-related cancers because HIV, the virus that causes AIDS, attacks their immune systems, leaving them unable to fight off other infections.
In the United States in the 1980s and early 1990s, the once-rare Kaposi sarcoma became a hallmark of the AIDS epidemic. It has since become rare again in the U.S. as antiretroviral drugs have kept HIV in check.
That’s not, unfortunately, the case in Uganda, despite gains made in increasing the number of people with HIV who are on lifelong medication. Only about half of those who need antiretroviral treatment receive it, and many start it later after diagnosis than those in the U.S. and don’t stay on it continuously.
Another difference, striking in the UCI ward, is that Kaposi sarcoma — like HIV/AIDS — is even more common among women than men in Uganda. In sub-Saharan Africa, HIV is spread predominately by heterosexual sex. In 2013, almost 60 percent of all new HIV infections among young people aged 15–24 occurred among adolescent girls and young women, according to the Foundation for AIDS Research.
Nabaggala, the mother of 9-year-old Nicholas and 2-year-old Anisha, was first referred to the UCI in March 2013 and underwent chemotherapy. Now the cancer has spread to her lungs. She was having trouble breathing, and has not been able to keep up her work selling second-hand clothing. Nabaggala and her husband are separated; his mother is tending the children while her younger sister stays at the hospital with her.
“My body is very weak,” she said, her eyes enormous in her small face. “Sometimes I’m very ill — I’m so ill I get scared.”
The prognosis for Kaposi sarcoma is fair, said Kibudde, the UCI physician, and excellent if the patient is receiving good HIV care. But too often, that is not the case. Sometimes patients only learn that they have HIV when they get diagnosed with Kaposi sarcoma — and it is already advanced. Other times, patients can be treated at an HIV clinic for months without being referred for chemotherapy to treat their cancer lesions.
The UCI-Hutchinson Center Cancer Alliance is helping to coordinate the launch of Uganda’s first integrated HIV-cancer clinic this summer, said Dr. Warren Phipps, a Kampala-based Fred Hutch researcher and medical director of the alliance. Funded by Walter Reed Hospital and the U.S. President’s Emergency Plan for AIDS Relief, or PEPFAR, it will be housed in the new UCI-Fred Hutch Cancer Centre, which will officially open next Thursday.
“So many people come in [to the UCI] with an AIDS-associated cancer,” Phipps said. “Antiretroviral therapy is a critical part of their cancer treatment.”